Methods for treating cancer in patients with elevated levels of BIM
US10259875B2 · kind B2 · utility
0Cited by
116References
10Claims
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Assignee
Inventors
Key dates
| Filing date | Sep 3, 2014 |
| Grant date | Apr 16, 2019 |
| Priority date | — |
| Expiry date | Sep 3, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Materials and methods for treating cancer especially in patients identified as having elevated levels of Bim are disclosed. Specifically, the disclosure provides a method for treating a mammal having cancer, the method comprises: (a) identifying said mammal as containing an elevated level of Bim, and (b) administering to said mammal an anti-B7-H1 antibody, an anti-PD-1 antibody, an anti-CD80 antibody, or a fusion protein comprising a portion of PD1 or a portion of CD80, under conditions wherein the interaction of naturally occurring B7-H1 with PD-1 or CD80 in said mammal is reduced after said administering.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.