Antibodies targeted to fungal cell wall polysaccharides
US10259888B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 1, 2017 |
| Grant date | Apr 16, 2019 |
| Priority date | — |
| Expiry date | May 1, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/627
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound comprising one or more polysaccharide moieties each independently represented by the formula β(1→4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.