Synthesis and micro-/nanostructuring of surface-attached crosslinked antimicrobial and/or antibiofouling polymer networks

US10259915B2 · kind B2 · utility

Assignees

• UNIVERSITAETSKLINIKUM FREIBURG · DE
• Albert-Ludwigs-Universitaet Freiburg · DE

Inventors

• Karen Lienkamp · Frankfurt, DE
• Jakob Belardi · Nürnberg, DE
• Peng Zou · Cambridge, US
• Ali Al-Ahmad · Glückstadt, DE
• Thorsten Steinberg · Mannheim, DE
• Pascal Tomakidi · Teningen, DE

Key dates

• Filing date: Mar 8, 2013
• Grant date: Apr 16, 2019
• Expiry date: Mar 14, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08J2345/00
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The present invention relates to substrates comprising a crosslinked network of covalently attached antimicrobial and/or antibiofouling polymers. The crosslinked network of antimicrobial and/or antibiofouling polymers acts highly efficiently against pathogens, e.g. bacteria and fungi. Both the antimicrobial and the antibiofouling cross-linked polymer networks are preferably better resistant to mechanical damage than simple surface-immobilized polymer monolayers. The antimicrobial and/or antibiofouling polymers of the crosslinked network are preferably obtained by ring opening metathesis polymerization (ROMP) and exhibit a molecular weight of preferably more than 30,000 or even 100,000 g mol−1. The crosslinked network of antimicrobial and/or antibiofouling polymers is preferably covalently attached to the surface of a substrate, e.g. an implant, a medical device, medical equipment or a (tissue-supporting) biomaterial, etc. The present invention is also directed to uses of crosslinked networks of antimicrobial and/or antibiofouling polymers as defined herein, e.g. for coating a surface of a substrate, and to methods therefore.