Patent · US Active

Random RNA libraries, methods of generating same, and screening methods utilizing same

US10260065B2 · kind B2 · utility

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28Claims

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Assignee

The Trustees of the University of Pennsylvania · US

Inventors

Robert B. Wilson · Overland Park, US
Yongping Wang · Zhejiang, CN

Key dates

Filing date	Aug 5, 2014
Grant date	Apr 16, 2019
Priority date	—
Expiry date	Sep 15, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N15/66
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

This invention provides sets and libraries of short hairpin ribonucleic acid (shRNA) molecules comprising a double-stranded region of random sequence containing random mismatches, methods of generating same, sets and libraries of expression vectors for same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.