Microfluidic devices and methods

US10260168B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Abraham P. Lee · Irvine, US
• Philip Felgner · Rancho Santa Fe, US
• Armando Tovar · San Diego, US
• Uland Liao · Irvine, US

Key dates

• Filing date: Feb 20, 2012
• Grant date: Apr 16, 2019
• Expiry date: Feb 22, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Contemplated microfluidic devices and methods are drawn to protein arrays in which distinct and detergent-containing antigen preparations are deposited onto an optical contrast layer in a non-specific and non-covalent manner. Detection of binding a is carried out using a dye that precipitates or agglomerates to so form a visually detectable signal at a dynamic range of at least three orders of magnitude.