Microarray having a base cleavable linker

US10261075B2 · kind B2 · utility

Assignee

• CustomArray, Inc. · US

Inventors

• Karl-Heinz Maurer · Erkrath, DE
• Dominic Suciu · Edmonds, US
• Hetian Gao · Fremont, US

Key dates

• Filing date: May 25, 2018
• Grant date: Apr 16, 2019
• Expiry date: May 25, 2038

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J2219/00722
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

There is disclosed a microarray having base cleavable linkers and a process of making the microarray. The microarray has a solid surface with known locations, each having reactive hydroxyl groups. The density of the known locations is greater than approximately 100 locations per square centimeter. Optionally, oligomers are synthesized in situ onto the cleavable linkers and subsequently cleaved using a cleaving base. Optionally, the oligomers are cleaved and recovered as a pool of oligomers.