Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement

US10265155B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Helen H. Lu · New York, US
• Jeffrey Spalazzi · Staten Island, US
• Kristen L. Moffat · Oakmont, US
• William N. Levine · New York, US

Key dates

• Filing date: Sep 30, 2014
• Grant date: Apr 23, 2019
• Expiry date: Nov 19, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.