Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof

US10265320B2 · kind B2 · utility

Assignees

• The Research Foundation for The State University of New York · US
• NEW YORK UNIVERSITY · US

Inventors

• Ann Marie Schmidt · Franklin Lakes, US
• Ravichandran Ramasamy · Ardsley, US
• Alexander Shekhtman · Glenmont, US
• Vivek Rai · Prayagraj, IN
• Michaele B. Manigrasso · New York, US

Key dates

• Filing date: May 25, 2016
• Grant date: Apr 23, 2019
• Expiry date: May 25, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.