Adverse side-effects associated with administration of an anti-hyaluronan agent and methods for ameliorating or preventing the side-effects
US10265410B2 · kind B2 · utility
1Cited by
66References
35Claims
0Family size
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Key dates
| Filing date | Apr 15, 2016 |
| Grant date | Apr 23, 2019 |
| Priority date | — |
| Expiry date | Jul 5, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y302/01035
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods involve systemically administering a PEGylated hyaluronan degrading enzyme, particularly a PEGylated hyaluronidase, such as any of the animal or bacterial hyaluronidases, to the subject and administering an amount of a corticosteroid sufficient to ameliorate the adverse effect. Also provided are method of treating a hyaluronan-associated disease or condition for single-agent therapy or combination therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.