Pyrrolic amide compound and preparation method and application thereof
US10266489B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 27, 2017 |
| Grant date | Apr 23, 2019 |
| Priority date | — |
| Expiry date | Jun 27, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a pyrrolic amide compound shown as a formula I, or crystal forms thereof, and pharmaceutically acceptable salts, hydrates or solvates, wherein R1 is selected from hydrogen, hydroxyl, cyano, halogen, carboxyl, C1-C6 alkyl and the like; R2 is selected from hydrogen, hydroxyl, cyano, halogen and the like; R3 is selected from hydroxyl and the like; X is selected from group, m is equal to 0, 1, 2 or 3, and n is equal to 0, 1 or 2. The novel compound shown as the formular I provided by the present invention has high deacetylase inhibitory viability; and meanwhile, a method for preparing the novel compound in the present invention has the advantages of fewer steps, simple and convenient operation, safety, environment friendliness, high yield and the like and is very suitable for industrial application.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.