Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment

US10267777B2 · kind B2 · utility

Assignee

• METABOLON, INC. · US

Inventors

• Michael Milburn · Cary, US
• John A. Ryals · Durham, US
• Lining Guo · Brownsburg, US
• Andrea Eckhart · Durham, US
• Jacob Wulff · Morrisville, US
• Adam D. Kennedy · Austin, US
• Thomas J. Jönsson · Durham, US
• Ryan Douglas Michalek · Durham, US
• Bryan Wittmann · Akron, US
• Matthew W. Mitchell · Durham, US

Key dates

• Filing date: Oct 7, 2016
• Grant date: Apr 23, 2019
• Expiry date: Oct 7, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods are described herein for small molecule biochemical profiling of an individual subject for diagnosis of a disease or disorder, facilitating diagnosis of a disease or disorder, and/or identifying an increased risk of developing a disease or disorder in the individual subject. Aberrant levels of small molecules present in a sample from an individual subject are identified and diagnostic information relevant to the individual subject is obtained based on the identified aberrant levels. The obtained diagnostic information includes one or more of an identification of at least one biochemical pathway associated with the identified subset of the small molecules having aberrant levels, an identification at least one disease or disorder associated with the identified subset of the small molecules having aberrant levels, and an identification of at least one recommended follow up test associated with the identified subset of the small molecules having aberrant levels.