HCV NS4A/modified NS3 polypeptides and uses thereof

US10267803B2 · kind B2 · utility

Assignee

• ORTHO-CLINICAL DIAGNOSTICS, INC. · US

Inventors

• David Chien · Emeryville, US
• Doris Coit · Petaluma, US
• Toshiya Fujihara · Urayasu, JP
• Alexander Gyenes · San Francisco, US
• John A. Hall · Abdulrahman Khaleefah Street, US
• Angelica Medina-Selby · San Francisco, US
• Jian Zheng · Longbeilingcun, CN

Key dates

• Filing date: Jun 22, 2015
• Grant date: Apr 23, 2019
• Expiry date: Jun 22, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2469/20
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Modified hepatitis C virus polypeptides are described. The polypeptides include the HCV NS4a domain and modified NS3 domain. The polypeptides retain conformational epitopes. HCV immunoassays including the polypeptides are also described.