Nanostructures comprising cobalt porphyrin-phospholipid conjugates and polyhistidine-tags

US10272160B2 · kind B2 · utility

Assignees

• The Research Foundation for The State University of New York · US
• PATH · US

Inventors

• Jonathan Lovell · Toronto, CA
• Shuai Shao · Hangzhou City, CN
• Jumin Geng · Williamsville, US
• Wei Huang · 红钢城街道, CN
• Shwu-Maan Lee · Rockville, US
• Charles Richter King · Washington, US

Key dates

• Filing date: Apr 18, 2016
• Grant date: Apr 30, 2019
• Expiry date: Apr 18, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/21
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides nanostructures (e.g., monolayer or bilayer nanostructures) comprising porphyrins with cobalt chelated thereto such that the cobalt metal resides within monolayer or bilayer in the porphyrin macrocycle. The nanostructures can have presentation molecules with a histidine tag attached thereto, such that at least a part of the his-tag is within the monolayer or bilayer and coordinated to the cobalt metal core and the presentation molecules are exposed to the outside of the nanostructures. The nanostructures can further comprise a cargo. The nanostructures can be used to deliver the cargo to an individual.