Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof
US10273206B2 · kind B2 · utility
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2Claims
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Key dates
| Filing date | Jun 27, 2014 |
| Grant date | Apr 30, 2019 |
| Priority date | — |
| Expiry date | Jun 27, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides tromethamine salt of (Z)-7-[3,5-Dihydroxy-2-((E)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline Form 1 and amorphous form. This compound is may also be referred to as “tromethamine salt of bimatoprost acid.” The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.