Substituted pyrimidine compounds, compositions and medicinal applications thereof

US10273224B2 · kind B2 · utility

Assignee

• JUBILANT BIOSYS LIMITED · IN

Inventors

• Chandregowda Venkateshappa · Noida, IN
• Dhanalakshmi Sivanandhan · Noida, IN
• Rajagopal Bakthavatchalam · Branford, US
• Raghava Reddy Kethiri · Noida, IN
• Vellarkad N. Viswanadhan · Nagamangala, IN
• Sanjeev Giri · Prayagraj, IN

Key dates

• Filing date: Jul 10, 2014
• Grant date: Apr 30, 2019
• Expiry date: Jul 10, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure relates to pyrimidine compounds of formula (I), their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to process of preparation of these pyrimidine compounds, and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases and disorders mediated by epidermal growth factor receptor (EGFR) family kinases.