4-phenylpiperidines, their preparation and use

US10273243B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Konstantin Petrukhin · Collegeville, US
• Christopher Cioffi · Troy, US
• Graham Johnson · Madison, US
• Nicoleta Dobri · New York, US
• Emily Freeman · Voorheesville, US
• Ping Chen · Fujian, CN
• Michael Conlon · Albany, US
• Lei Zhu · Hefei, CN

Key dates

• Filing date: Mar 13, 2014
• Grant date: Apr 30, 2019
• Expiry date: Mar 13, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.