Pro-drug forming compounds

US10273263B2 · kind B2 · utility

Assignee

• Evestra, Inc. · US

Inventors

• Klaus Nickisch · Berlin, DE
• Bindu Santhamma · San Antonio, US
• Gulzar Ahmed · Yardley, US
• Frederick Meece · San Antonio, US
• Walter Elger · Berlin, DE
• Ralf Wyrwa · Kahla, DE
• Hareesh Nair · San Antonio, US

Key dates

• Filing date: Aug 24, 2017
• Grant date: Apr 30, 2019
• Expiry date: Aug 24, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J51/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Various prodrug compounds having the general structure: Active agent—(acid)-(linker)—SO2NR1R2 are described herein. Compounds having this general structure were shown to be more orally active than the unmodified parent molecule.