Chimeric antigen receptors (CARs), targeting hematologic malignancies, compositions and methods of use thereof

US10273280B2 · kind B2 · utility

Assignee

• iCell Gene Therapeutics LLC · US

Inventors

• Yupo Ma · Las Vegas, US
• Kevin PINZ · Stony Brook, US
• Xun JIANG · Stony Brook, US
• Masayuki Wada · Stony Brook, US
• Kevin Chen · Beijing, CN

Key dates

• Filing date: Feb 26, 2016
• Grant date: Apr 30, 2019
• Expiry date: Feb 26, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16043
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides chimeric antigen receptor polypeptides having antigen recognition domains for CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens, and polynucleotides encoding for the same. The present disclosure also provides for engineered cells expressing the polynucleotide or polypeptides. In some embodiments, the disclosure provides methods for treating diseases associated with CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens.