Chimeric antigen receptor specific for SSEA4 antigen

US10273295B2 · kind B2 · utility

Assignee

• Miltenyi Biotec, Inc. · DE

Inventors

• Andreas Bosio · Cologne, DE
• Olaf Hardt · Cologne, DE
• Andrea Aloia · Zürich, CH

Key dates

• Filing date: Aug 12, 2015
• Grant date: Apr 30, 2019
• Expiry date: Sep 20, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/33
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain specific for SSEA4, a population of engineered cells expressing said CARs, and a pharmaceutical composition comprising said genetically modified cells expressing said CARs. The pharmaceutical composition may be for use of the treatment of cancer in a subject suffering from cancer, wherein at least a subpopulation of the cancerous cells of said cancer expresses SSEA4.