Substituted polyesters by thiol-ene modification: rapid diversification for therapeutic protein stabilization
US10273333B2 · kind B2 · utility
2Cited by
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20Claims
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Key dates
| Filing date | Dec 29, 2016 |
| Grant date | Apr 30, 2019 |
| Priority date | — |
| Expiry date | Dec 29, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G2230/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5—[R1R2C—CR3R4]n-[DG]m—R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (—OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.