Compounds and methods for enhancing viral gene transfer to human hematopoietic cells
US10273503B2 · kind B2 · utility
0Cited by
3References
22Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Sep 17, 2015 |
| Grant date | Apr 30, 2019 |
| Priority date | — |
| Expiry date | Sep 17, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/15043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions for enhancing viral gene transfer, such as lentiviral gene transfer, and improving the efficacy of gene delivery to cells such as primitive hematopoietic cells, are described. These methods and compositions are based on the use of pyrimido[4,5-b]indole derivatives. Cell-based compositions and methods useful for therapeutic indications amenable to treatment with gene therapies, including hematopoietic stem cell therapies, are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.