Biomarkers for detecting and monitoring colon cancer
US10274496B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 16, 2015 |
| Grant date | Apr 30, 2019 |
| Priority date | — |
| Expiry date | Apr 2, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/56
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A metabolic profiling approach for identifying biomarkers that provide highly sensitive and specific colorectal cancer (CRC) detection and monitoring using serum samples. The methods can be used for distinguishing CRC patients from both healthy controls and polyp patients, as well as to monitor disease progression or response to therapy. Receiver operator characteristic curves generated based on these models showed high sensitivities for differentiating CRC patients from healthy controls or polyp patients, good specificities, low false discovery rates, and excellent areas under the curve were obtained. Monte Carlo cross validation (MCCV) was also applied, demonstrating the robust diagnostic power of this metabolic profiling approach.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.