Hydroxyl purine compounds and use thereof

US10278973B2 · kind B2 · utility

Assignee

• GUANGDONG RAYNOVENT BIOTECH CO., LTD. · CN

Inventors

• Lingyun WU · Shanghai, CN
• Xiaoxin Chen · Cupertino, US
• Peng Zhang · Nanhu, CN
• Xing Liu · Hefei, CN
• Li Zhang · New Milford, US
• Zhuowei Liu · 流花街道, CN
• Shuhui CHEN · Shanghai, CN
• Chaofeng Long · Tangxia, CN

Key dates

• Filing date: May 5, 2016
• Grant date: May 7, 2019
• Expiry date: May 5, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/525
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNFα inhibitors, in particular, the compounds as shown in formula (I), or tautomers thereof or pharmaceutically acceptable salts thereof.