Methods for promoting hematopoietic reconstitution
US10278990B2 · kind B2 · utility
0Cited by
6References
14Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Mar 15, 2013 |
| Grant date | May 7, 2019 |
| Priority date | — |
| Expiry date | Sep 27, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N5/0647
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.