Immunogenic compositions for inducing an immune response for elimination of senescent cells
US10279018B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 3, 2013 |
| Grant date | May 7, 2019 |
| Priority date | — |
| Expiry date | Mar 19, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/64
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are immunogenic compositions (vaccines) and methods for immunizing a subject with the immunogenic compositions for inducing an adaptive immune response directed specifically against senescent cells for treatment and prophylaxis of age-related diseases and disorders, and other diseases and disorders associated with or exacerbated by the presence of senescent cells. The immunogenic compositions provided herein comprise at least one or more senescent cell-associated antigens, polynucleotides encoding senescent cell-associated antigens, and recombinant expression vectors comprising the polynucleotides for use in administering to a subject in need thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.