Process for preparing 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro-phenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-N-((1S,2S)-2-hydroxycyclohexyl) benzamide or a pharmaceutically acceptable salt thereof

US10280155B2 · kind B2 · utility

Assignee

• PULMOCIDE LIMITED · GB

Inventors

• Thomas Christopher Colley · London, GB
• Kazuhiro Ito · London, GB
• Peter Strong · London, GB
• Mihiro Sunose · Sawston, GB
• Matthew McConville · Nottingham, GB

Key dates

• Filing date: May 4, 2018
• Grant date: May 7, 2019
• Expiry date: May 4, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for preparing a compound of formula (I): or a pharmaceutically acceptable salt thereof includes reacting a compound of formula (6): (wherein R is H) with 2-aminocyclohexanol or a salt thereof.