Nicotinic acid riboside or nicotinamide riboside compositions, reduced derivatives thereof, and the use thereof to enhance skin permeation in treating skin conditions
US10280190B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 16, 2016 |
| Grant date | May 7, 2019 |
| Priority date | — |
| Expiry date | May 31, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q19/007
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including 1-(2′,3′,5′-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid (4a), and compositions containing the same and/or reduced derivative forms of nicotinamide riboside including 1-(2′,3′,5′-triacetyl-beta-D-ribofuranosyl)-1,4-nicotinamide (2), are provided for use in the care of treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing one or more NR, NAR, NRH, or NARH derivatives, or prodrugs or salts thereof. In further embodiments, the invention relates to methods of using one or more NR, NAR, NRH, or NARH derivatives, or prodrugs, solvates, or salts thereof, to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival and overall cell and tissue health.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.