Linkers and their application towards ADC
US10280229B2 · kind B2 · utility
0Cited by
3References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 13, 2015 |
| Grant date | May 7, 2019 |
| Priority date | — |
| Expiry date | Aug 13, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/73
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.