Immune-compatible cells created by nuclease-mediated editing of genes encoding HLA
US10280402B2 · kind B2 · utility
1Cited by
5References
14Claims
0Family size
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Key dates
| Filing date | Aug 6, 2015 |
| Grant date | May 7, 2019 |
| Priority date | — |
| Expiry date | Aug 6, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method for producing immune-compatible cells or a cell population which comprises a step of editing one or two alleles of one or more immune-compatible antigen genes by gene deletion or modification in an isolated cell comprising at least one of the immune-compatible antigen genes selected from HLA (human leukocyte antigen)-A, HLA-B and HLA-DR, to immune-compatible cells produced by the method, and to a cell population comprising the immune-compatible cells produced by the method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.