Methods of resolving racemic mixture to obtain (−)-huperzine A
US10287249B2 · kind B2 · utility
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Key dates
| Filing date | Jun 26, 2015 |
| Grant date | May 14, 2019 |
| Priority date | — |
| Expiry date | Jun 26, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of resolving a racemic mixture of (±)-Huperzine A to (−)-Huperzine A includes: separating the (−)-Huperzine A from the racemic mixture of (±)-Huperzine A by chiral high performance liquid chromatography (HPLC), the chiral HPLC being performed utilizing a mobile phase including a solution including an alcohol and one selected from dichloromethane, trichloromethane, and a mixture thereof, and the chiral HPLC being performed utilizing a chiral stationary phase including a polysaccharide derivative.
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