Compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions comprising the same
US10287255B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 12, 2015 |
| Grant date | May 14, 2019 |
| Priority date | — |
| Expiry date | Mar 12, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of formula (I), having histone deacetylase 6 (HDAC6) inhibitory activity, wherein X, Q, N, R1, R2, L, and n are as described, isomers thereof, or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions comprising the same, a method of treating disease using the composition, and methods for preparing the novel compounds. The novel compounds according to the present invention have histone deacetylase 6 (HDAC6) inhibitory activity, and are effective for the prevention or treatment of HDAC6-associated diseases, including cancer, inflammatory diseases, autoimmune diseases, neurological diseases and neurodegenerative disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.