Indole compounds having antiprotozoal activity and its use as well as methods for producing the same

US10287271B2 · kind B2 · utility

Assignees

• TECHNISCHE UNIVERSITAT BRAUNSCHWEIG · DE
• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Conrad Kunick · Hamburg, DE
• Hoang Lande · Braunschweig, DE
• Johann Gruenefeld · Gifhorn, DE
• Ron Dzikowski · Jerusalem, IL
• Abed Nasereddin · Jerusalem, IL

Key dates

• Filing date: Jul 10, 2015
• Grant date: May 14, 2019
• Expiry date: Jul 10, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

In a first aspect, the present invention relates to new compounds as depicted in formula (I). In particular, compounds according to the present invention are bisindolylcyclobuten-dione-based structures having antiprotozoal activity. In a further aspect, pharmaceutical compositions containing the same are provided as well as the use of the compounds and pharmaceutical compositions for the prophylaxis and treatment of parasite based diseases including malaria. Finally, methods for the treatment of parasite diseases including malaria are provided.