Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof

US10287284B2 · kind B2 · utility

Assignee

• VTV THERAPEUTICS LLC · US

Inventors

• Adnan M. M. Mjalli · Oak Ridge, US
• Dharma Rao Polisetti · High Point, US
• Jareer Nabeel Kassis · Colfax, US
• Matthew J. Kostura · Hillsborough, US
• Mustafa Guzel · Jamestown, US
• Otis Clinton Attucks · Winston-Salem, US
• Robert Carl Andrews · Jamestown, US
• Samuel Victory · Oak Ridge, US
• Suparna Gupta · Greensboro, US

Key dates

• Filing date: Jun 13, 2018
• Grant date: May 14, 2019
• Expiry date: Jun 13, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.