Nitrogen-containing analogs of salinomycin, synthesis and use against cancer stem cells and malaria
US10287298B2 · kind B2 · utility
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Key dates
| Filing date | Sep 14, 2015 |
| Grant date | May 14, 2019 |
| Priority date | — |
| Expiry date | Sep 14, 2035 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns compounds of formula (I), enantiomers, mixture of enantiomers, diastereoisomers and mixture of diasteroisomers thereof formula (I): wherein at least one of W, X and Y is selected from the group consisting of —NR1R2; —NR3—(CH2)n—NR4R5; —O—(CH2)n—NR4R5; —NR3—(CH2)n—N′R6R7R8; and —O—(CH2)n—N′R6R7R8 and Z is a functional group capable of chelating iron salts. The present invention also concerns the compounds of formula (I) for use as a drug, in particular, in the treatment of cancer and malaria.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.