Patent · US Active

Protein scaffolds and methods of use

US10287572B2 · kind B2 · utility

0Cited by

16References

9Claims

0Family size

Assignee

Regents of the University of Minnesota · US

Inventors

Benjamin Hackel · Edina, US
Max A. Kruziki · Windom, US
Sumit Bhatnagar · Ann Arbor, US
Hong Zhou · Wilmington, US

Key dates

Filing date	Oct 31, 2014
Grant date	May 14, 2019
Priority date	—
Expiry date	Oct 31, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2795/10232
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This disclosure describes non-naturally occurring protein scaffolds and methods of making and using the protein scaffolds. In one aspect, therefore, this disclosure describes a non-naturally occurring protein scaffold that includes a plurality of structural domains and a plurality of loop regions that include an amino acid sequence that varies from a naturally-occurring loop region by at least one amino acid deletion, substitution, or addition. Generally, the structural domain or domains can include at least one β structure and/or at least one a helix.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.