Tissue selective transgene expression

US10287607B2 · kind B2 · utility

Assignee

• Encoded Therapeutics, Inc. · US

Inventors

• Stephanie TAGLIATELA · San Francisco, US
• Andrew YOUNG · South San Francisco, US
• Szu-Ying CHEN · San Francisco, US
• Kartik Ramamoorthi · South San Francisco, US
• David OBERKOFLER · San Francisco, US

Key dates

• Filing date: Oct 5, 2018
• Grant date: May 14, 2019
• Expiry date: Oct 5, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2840/007
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.