Two-dimensional semi-LASER correlation spectroscopy with well-maintained cross peaks
US10288704B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Apr 4, 2014 |
| Grant date | May 14, 2019 |
| Priority date | — |
| Expiry date | Dec 24, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/485
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A sLASER-first-COSY sequence is disclosed. After a delay time, Δ1, from application of a first 90° radio frequency (RF) pulse, a first pair of adiabatic full-passage (AFP) pulses are applied to an object in a MRI scanner. The first 90° RF pulse is a non-adiabatic slice-selective 90° RF pulse and the first pair of AFP pulses is separated by an inter-pulse time interval, Δ2. A second pair of AFP pulses, separated by the time Δ2, is then applied, followed by a second 90° RF pulse. The second 90° RF pulse is a non-adiabatic non-slice-selective 90° RF pulse. MR signal is acquired after an echo time (TE) from application of the excitation RF pulse. The present method may achieve intended full magnetization transfer between a coupled spin pair of a metabolite and maintain metabolite cross peak intensity of a coupled spin pair of a metabolite in the object.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.