Optogenetics microscope
US10288863B2 · kind B2 · utility
1Cited by
41References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 20, 2016 |
| Grant date | May 14, 2019 |
| Priority date | — |
| Expiry date | May 20, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG02B21/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides an open-stage near-TIRF microscope in which all of the optical components are positioned underneath the sample, allowing for physical access to, and control over the environment of, the sample. The microscope can be used to image cells expressing fluorescent voltage indicators. Since the TIRF components do not interfere with the sample, living cells can be studied using a microscope of the invention. Where a sample includes electrically active cells expressing fluorescent voltage indicators, the microscope can be used to view voltage changes in, and thus the electrical activity of, those cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.