Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea
US10292865B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 20, 2015 |
| Grant date | May 21, 2019 |
| Priority date | — |
| Expiry date | Jul 20, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2009/00895
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.