Polymeric micelle particle comprising anionic drugs and method of preparing the same
US10292932B2 · kind B2 · utility
2Cited by
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16Claims
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Key dates
| Filing date | Apr 25, 2016 |
| Grant date | May 21, 2019 |
| Priority date | — |
| Expiry date | Apr 25, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are an anionic drug-containing polymeric micelle particle comprising: an anionic drug as an active ingredient; a cationic lipid; and an amphiphilic block copolymer, wherein the anionic drug forms a complex with the cationic lipid, and the complex is entrapped in the micelle structure of the amphiphilic block copolymer, and a method for preparing the same. The particle may increase stability of the anionic drug in blood or in a body fluid, and it may enable intracellular delivery to improve efficacy of anionic drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.