Patent · US Active

Methods for increasing blood plasma 2′-deoxyuridine (dUrd) and thymidylate synthase inhibition

US10292984B2 · kind B2 · utility

2Cited by

3References

16Claims

0Family size

Assignee

Isofol Medical AB · SE

Inventors

Göran Carlsson · Stenhamra, SE
Bengt Gustavsson · Mörbylånga, SE
Elisabeth Odin · Göteborg, SE
Yvonne Wettergren · Göteborg, SE
Anders Vedin · Göteborg, SE

Key dates

Filing date	Feb 9, 2018
Grant date	May 21, 2019
Priority date	—
Expiry date	Feb 9, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/76
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides methods for increasing plasma dUrd levels comprising the administration of 6R-MTHF. The methods of increasing plasma dUrd increase dUrd levels compared to equimolar concentrations of LV. The present invention also provides methods for increasing TS inhibition comprising the administration of 6R-MTHF. The present invention also provides methods for increasing TS inhibition comprising the administration of 6R-MTHF.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.