Selective high-affinity polydentate ligands and methods of making such

US10292992B2 · kind B2 · utility

Assignees

• Lawrence Livermore National Security, LLC · US
• The Regents of the University of California · US

Inventors

• Sally J. DeNardo · El Macero, US
• Gerald L. DeNardo · El Macero, US
• Rodney L. Balhorn · Livermore, US

Key dates

• Filing date: Sep 13, 2017
• Grant date: May 21, 2019
• Expiry date: Sep 13, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.