Histotripsy excitation sequences optimized for bubble cloud formation using shock scattering
US10293187B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 3, 2014 |
| Grant date | May 21, 2019 |
| Priority date | — |
| Expiry date | Nov 26, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N2007/0078
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Methods and devices for producing cavitation in tissue are provided. In one embodiment, a shock scattering method of Histotripsy therapy comprises delivering an initiation pressure waveform from an ultrasound therapy transducer into tissue, the initiation pressure waveform being configured to produce at least one bubble in the tissue, delivering a scattering pressure waveform from the ultrasound therapy transducer into the at least one bubble within a life-cycle of the at least one bubble, and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. The scattering pressure waveform can be delivered during the life-cycle of the at least one bubble. In some embodiments, the scattering pressure waveform is delivered within 5 μs to 1 s of the initiation pressure waveform. Systems for performing shock scattering Histotripsy therapy are also discussed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.