Controlling the architecture, coordination, and reactivity of nanoparticle coating utilizing an amino acid central scaffold
US10294213B2 · kind B2 · utility
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Key dates
| Filing date | Dec 1, 2016 |
| Grant date | May 21, 2019 |
| Priority date | — |
| Expiry date | Jun 9, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC09K11/883
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A series of multicoordinating and multifunctional ligands optimized for the surface-functionalization of luminescent quantum dots (QDs) and gold nanoparticles (AuNPs) alike is disclosed. An L-aspartic acid precursor is modified with functionality, through simple peptide coupling chemistry, one or two lipoic acid (LA) groups and poly(ethylene glycol) (PEG) moieties in the same ligand. These ligands were combined with a new photoligation strategy to yield hydrophilic and reactive QDs that are colloidally stable over a broad range of conditions, including storage at nanomolar concentration and under ambient conditions.
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