Small molecule inhibitors of the JAK family of kinases

US10294226B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Tatiana Koudriakova · Poway, US
• Kevin D. Kreutter · Plainsboro, US
• Kristi A. Leonard · West Chester, US
• Michele C. Rizzolio · Durham, US
• Russell C. Smith · San Diego, US
• Mark S. Tichenor · San Diego, US
• Aihua Wang · Jamison, US

Key dates

• Filing date: Dec 15, 2017
• Grant date: May 21, 2019
• Expiry date: Dec 15, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.