Polypeptide ligands specific for plasma kallikrein
US10294274B2 · kind B2 · utility
16Cited by
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2Claims
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Key dates
| Filing date | Oct 28, 2014 |
| Grant date | May 21, 2019 |
| Priority date | — |
| Expiry date | Jan 26, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are specific for the human and rat protease plasma kallikrein and are modified in one or two peptide loops to enhance potency and/or protease resistance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.