Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom

US10294278B2 · kind B2 · utility

Assignees

• VGX PHARMACEUTICALS, LLC · US
• The Trustees of the University of Pennsylvania · US

Inventors

• David B. Weiner · Yeadon, US
• Bernadette Ferraro · Philadelphia, US
• Jian Yan · Wallingford, US
• Patricia A. Brown · Magnolia, US
• Rodney A. Bowling · Austin, US
• Douglas R. Kern · The Woodlands, US
• Mathura P. Ramanathan · Ardmore, US
• Niranjan Y. Sardesai · Blue Bell, US
• Karuppiah Muthumani · Cherry Hill, US

Key dates

• Filing date: Aug 3, 2015
• Grant date: May 21, 2019
• Expiry date: Aug 3, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2469/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.