Synthetic antibodies to BAX and uses thereof

US10294294B2 · kind B2 · utility

Assignees

• Albert Einstein College of Medicine · US
• The Governing Council of the University of Toronto · CA

Inventors

• Evripidis Gavathiotis · Boston, US
• Jonathan R. Lai · Dobbs Ferry, US
• Sachdev Sidhu · Toronto, CA

Key dates

• Filing date: Aug 25, 2016
• Grant date: May 21, 2019
• Expiry date: Aug 25, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2510/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Synthetic fragment antigen-binding (Fab) antibodies are disclosed that bind to an N-terminal activation site of BCL-2-associated X-protein (BAX) and inhibit BAX activation. Also disclosed are methods of using the Fabs for measuring inactive monomeric BAX levels, screening for small molecules that bind to an N-terminal activation site of BAX, inhibiting apoptotic cell death, and predicting the ability of a cancer therapy to promote apoptotic cell death.