Process for preparing poly(glycolide-co-lactide) copolymer microparticles

US10294337B2 · kind B2 · utility

Assignee

• Evonik Röhm GmbH · DE

Inventors

• Andreas Kirchner · Andernach, DE
• Rosario Lizio · Dieburg, DE
• Markus Rolf Rossmeissl · Darmstadt, DE
• Wolfgang Luley · Griesheim, DE
• Johannes Vorholz · Alzenau, DE
• Silko Grimm · Roßdorf, DE
• Marc Schneider · Walheim, DE

Key dates

• Filing date: Jun 21, 2016
• Grant date: May 21, 2019
• Expiry date: Jun 21, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08J2367/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for preparing poly(lactide-co-glycolide) copolymer particles with an average particle size in the range of 50-800 nm includes transferring a mixture of poly(lactide-co-glycolide) copolymer, ethanol and carbon dioxide from a first reactor into a second reactor under rapid reduction of the pressure and expansion with phase separation into a gas phase, an ethanol aerosol and an ethanolic suspension containing poly(lactide-co-glycolide) copolymer particles, removing the carbon dioxide gas and the ethanol aerosol from the second reactor, and obtaining the poly(glycolide-co-lactide) copolymer particles in the form of an ethanolic suspension or in dry form from the second reactor.