Development and use of fluorescent probes of unbound bilirubin
US10295551B2 · kind B2 · utility
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2References
14Claims
0Family size
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Key dates
| Filing date | Nov 17, 2016 |
| Grant date | May 21, 2019 |
| Priority date | — |
| Expiry date | Mar 15, 2037 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/146666
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Identification and use of proteins fluorescently labeled and that undergo a change in fluorescence index upon binding bilirubin are described. Probes are disclosed which are labeled at a cysteine or lysine residue and also probes labeled at both cysteine and lysine with two different fluorophores. These probes are useful for determination of unbound bilirubin levels in a fluid sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.